Thoracic aorta stent graft

ABSTRACT

A stent graft for placement in a vessel of a patient, the stent graft that has a tubular body of graft material, the tubular body having a proximal inflow end, a distal outflow end, a main lumen therethrough, a longitudinal access, and a sidewall from the first end to the second end. At least one stent is along the length of the tubular body. One or more shaped recesses are formed of a concave or recessed portion of graft material that extends into the lumen of the stent graft. A fenestration is in the recessed portion with a fenestration and an internal branch extends from the or each fenestration toward the proximal end of the tubular body of graft material. The internal branch may have a tubular portion and a funnel portion, wherein the tubular portion extends into the main lumen and the enlarged funnel portion is attached to sidewall and forms the at least one shaped recess.

RELATED APPLICATIONS

This application is a continuation of U.S. Ser. No. 16/511,516, filedJul. 15, 2019, which is a continuation of U.S. Ser. No. 16/287,239,filed Feb. 27, 2019, now, U.S. Pat. No. 10,485,651, which is acontinuation of U.S. Ser. No. 15/593,715, filed May 12, 2017, now U.S.Pat. No. 10,231,822, which is a continuation of U.S. Ser. No.13/576,348, filed Jul. 31, 2012, now U.S. Pat. No. 9,649,188, which is aNational Stage of International Application No. PCT/US2011/024148, filedFeb. 9, 2011, which claims the benefit of the filing date under 35U.S.C. § 119(e) of Provisional U.S. Patent Application Ser. No.61/302,586, filed Feb. 9, 2010. All of the foregoing applications arehereby incorporated by reference in their entirety.

BACKGROUND 1. Technical Field

This invention relates to a medical device for treatment of aortic archdisease and more particularly to a stent graft for deployment into thethoracic aorta of a patient for that purpose.

2. Background Information

In recent years endovascular implantable devices have been developed fortreatment of aortic aneurysms. These devices are delivered to thetreatment site through the vascular system of the patient rather than byopen surgery. The devices include a tubular or cylindrical framework orscaffolding of one or more stents to which is secured a tubular shape ofgraft material such as woven Dacron, polyester polytetrafluoroethyleneor the like. The devices are initially reduced to a small diameter,placed into the leading or proximal end of a catheter delivery systemwhereafter the delivery system is inserted into the vascular system ofthe patient such as through a femoral incision. The leading end of thedelivery system is manoeuvred to the treatment site over a previouslypositioned guide wire. Through manipulation of a control system thatextends to the proximal end of the catheter from the distal end of thesystem outside the patient the implantable device is then deployed byholding the device at its location and withdrawing a surrounding sheath.The stent graft or implantable device can then self expand or isexpanded through the use of a balloon which is introduced with the stentgraft introduction device. The stent graft becomes anchored intoposition to healthy wall tissue in the aorta such as by barbs whereafterthe delivery system is then removed leaving the device in position toreverse an aneurysm in the aorta in a manner that channels all bloodflow through the stent graft so that no blood flow enters the aneurysmthereafter, such that not only does the aneurysm no longer continue togrow and possibly rupture but the aneurysm actually begins to shrink andcommonly disappears entirely.

For treatment of thoracic aortic aneurysms in particular it is necessaryto introduce the implantable device high up in the aorta and in a regionof the aorta which is curved and where there can be strong blood flow.

In the thoracic aorta there are major branch vessels, thebrachiocephalic, the left carotid and the left subclavian and fortreatment of an aneurysm in the region of the thoracic arch provisionmust be made for blood supply to continue to these arteries. For thispurpose fenestrations are provided into the wall of a stent graft inthat region. Access is generally obtained to these fenestrations, todeploy side arms into the stent graft, via the left or right brachialarteries or less commonly via the left or right carotid arteries. Onceinto the thoracic arch via such an artery the fenestration in the stentgraft must be catheterised.

If a stent graft has been deployed into the thoracic aorta around thearch such that its fenestrations are not aligned precisely with theircorresponding great vessels of the arch, then it can be difficult toaccess the fenestrations through corresponding vessels (such as thebrachiocephalic and the left brachial arteries).

It is the object of this invention to provide an arrangement of stentgraft to overcome the above problem or to at least provide thepractitioner with a useful alternative.

Throughout this specification the term distal with respect to a portionof the aorta, a deployment device or a prosthesis such as a stent graftis intended to mean the end of the aorta, deployment device orprosthesis such as a stent graft further away in the direction of bloodflow from the heart and the term proximal is intended to mean theportion of the aorta, deployment device or end of the prosthesis nearerto the heart. For other lumens within the human or animal body the termscaudal and cranial respectively should be understood.

Throughout this discussion the term “stent graft” is intended to mean adevice which has a tubular body of biocompatible graft material and atleast one stent fastened to the tubular body to define a lumen throughthe stent graft. The stent graft may be bifurcated and havefenestrations, side arms or the like. Other arrangements of stent graftsare also within the scope of the invention.

BRIEF SUMMARY

In one form therefore the invention is said to reside in a stent graftfor placement in the thoracic arch of a patient, the stent graftcomprising:

a tubular body defining a main lumen therethrough, a plurality of zigzag stents along the tubular body, each of the stents comprising aplurality of struts and bends, the bends being between adjacent struts;

at least a first stent and an adjacent second stent, the first andsecond stents having at least a pair of adjacent bends on the firststent aligned with an adjacent pair of bends on the second stent,whereby a first pair of adjacent struts of the first stent and a secondpair of adjacent struts of the second adjacent stent together define adiamond shaped region;

a recess in the diamond shaped region, the recess being defined by aconcave portion of graft material and the recess extending into thelumen of the tubular body, the recess having a proximal end;

a fenestration in the concave portion of graft material, thefenestration opening into the tubular body within the recess in thediamond shaped region; and

a graft tube leading from the fenestration into the main lumen.

Preferably the fenestration and graft tube extend from the proximal endof the recess.

In one form the stent graft further comprises:

a third adjacent stent, the third adjacent stent having at least a pairof bends adjacent to the second stent whereby a third pair of adjacentstents of the third strut defines a second diamond shaped region,

wherein the second diamond shaped region shares a strut with the firstdiamond shaped region.

Preferably the stent graft comprises one, two or three diamond shapedregions, each diamond shaped region comprising a respective recess,fenestration and graft tube.

Preferably the stent graft comprises a proximal end and a distal end andthe, or each, graft tube extends within the main lumen towards theproximal end of the stent graft.

Preferably the bends and adjacent struts define an included angle in therange of from 40 to 80 degrees.

Preferably proximally of the diamond shaped region the tubular body hasa first diameter, distally of the diamond shaped region the tubular bodyhas a second diameter and in a region of the tubular body around thediamond shaped region the tubular body has a third diameter, the firstdiameter being greater than the second diameter and both the first andsecond diameter being greater than the third diameter whereby a centralregion is defined which will allow at least part circumferential bloodflow during an operation out of the graft tube into the recess and theninto the central region.

It will be seen that by this invention there is provided a stent graftfor placement in the thoracic arch of a patient. The stent graft can beplaced such that the intermediate portion is just proximal of thebrachiocephalic artery and on the outside of the curve of the thoracicarch. By this placement there is defined, by the difference in diameterof the first and second portions, an open region outside the stent graftdistal of the aperture in the step portion, so that blood flow can occurthrough the aperture to the open region enabling circulation to bepreserved to the major vessels through the internal branches during theprogress of an operation. As the intermediate portion is of stent graftis of a lesser diameter there is provided a working space in the recessin which a guide wire from the branch arteries can be directed to enterthe internal tube to enable catheterisation. Subsequently a side branchstent graft can be deployed from the respective branch artery into thetube to provide blood flow into that branch artery.

In a preferred embodiment the first diameter can be from 35 to 50 mm,the second diameter can be from 40 to 30 mm, the third diameter can befrom 20 to 40 mm. For instance in one embodiment the first diameter is46 mm and the second and third diameters are 38 mm. In anotherembodiment the first and third diameters are 36 mm and the thirddiameter is 24 mm.

In one form the stents are formed from nitinol.

In one form the or each graft tube comprises a reinforcement in the formof a space frame.

In one form the space frame comprises a cylindrical portion thecylindrical portion comprising first and second circular ring portionsspaced apart axially and at least two struts extending between the firstand second circular ring portions and the graft tube being around thespace frame.

In one form the cylindrical portion comprises an assembly of twoindividual ring and strut components, each ring and strut componentcomprising a circular ring portion defining a plane of the circular ringportion and a strut extending at right angles to the plane of thecircular ring portion from a periphery of the circular ring portion.

In an alternative form the invention is said to reside in a stent graftfor placement in the thoracic arch of a patient, the stent graftcomprising:

a tubular body defining a main lumen therethrough, a plurality of zigzag stents along the tubular body, each of the stents comprising aplurality of struts and points or bends, the points or bends beingbetween adjacent struts;

a shaped recess in the tubular body having a perimeter, the perimeterbeing formed at least in part at two adjacent struts of a first stentand two adjacent struts of a second adjacent stent;

the shaped recess being defined by a concave portion of graft materialand the shaped recess extending into the lumen of the tubular body, theshaped recess having a proximal end;

a fenestration in the concave portion of graft material, thefenestration opening into the tubular body within the shaped recess; and

a graft tube leading from the fenestration into the main lumen.

Preferably the fenestration and graft tube extend from the proximal endof the shaped recess.

In one form the stent graft further comprises:

a second shaped recess in the tubular body defined by a secondperimeter, the second perimeter being formed at least in part at twoadjacent struts of the second stent and two adjacent struts of a thirdadjacent stent.

In one form the stent graft further comprises: a proximal end and adistal end and the or each graft tube extends within the main lumentowards the proximal end of the stent graft.

Preferably the bends and adjacent struts define an included angle in therange of from 40 to 80 degrees.

In one form the stents are formed from nitinol.

In one form the or each graft tube comprises a reinforcement in the formof a space frame.

In one form the space frame comprises a cylindrical portion thecylindrical portion comprising first and second circular ring portionsspaced apart axially and at least two struts extending between the firstand second circular ring portions and the graft tube being around thespace frame.

In one form the cylindrical portion comprises an assembly of twoindividual ring and strut components, each ring and strut componentcomprising a circular ring portion defining a plane of the circular ringportion and a strut extending at right angles to the plane of thecircular ring portion from a periphery of the circular ring portion.

In a further alternative form the invention is said to reside in a stentgraft for placement in the thoracic arch of a patient, the stent graftcomprising:

a tubular body defining a main lumen therethrough, a plurality of zigzag stents along the tubular body, each of the stents comprising aplurality of struts and bends, the bends being between adjacent struts;

at least a first stent and an adjacent second stent, the first andsecond stents having at least a pair of adjacent bends on the firststent aligned with an adjacent pair of bends on the second stent,whereby a first pair of adjacent struts of the first stent and a secondpair of adjacent struts of the second adjacent stent together define adiamond shaped region;

a recess in the diamond shaped region, the recess being defined by aconcave portion of graft material and the recess extending into thelumen of the tubular body, the recess having a proximal end;

a fenestration in the concave portion of graft material, thefenestration opening into the tubular body within the recess in thediamond shaped region; and

a graft tube leading from the fenestration into the main lumen, thefenestration and graft tube extending from the proximal end of therecess towards the proximal end of the stent graft.

BRIEF DESCRIPTION OF THE DRAWINGS

This then generally describes the invention but to assist withunderstanding reference will now be made to the accompanying drawingswhich show preferred embodiments of the invention.

In the drawings:

FIG. 1 shows a plain view of a first embodiment of a stent graftaccording to the present invention;

FIG. 2 shows a side view of the stent graft of FIG. 1;

FIG. 3 is an isometric view looking in a slightly distal direction alongthe stent graft of FIG. 2;

FIG. 4 shows a view from the proximal end of the stent graft shown inFIG. 1;

FIG. 5 shows a longitudinal cross-sectional view of the stent graftshown in FIG. 1;

FIG. 6 shows a schematic view of the placement of a stent graftaccording to the present invention into the thoracic arch of a patient;and

FIG. 7 shows a plan view of a second embodiment of a stent graftaccording to the present invention.

DETAILED DESCRIPTION OF THE DRAWINGS AND THE PRESENTLY PREFERREDEMBODIMENTS

FIGS. 1 to 6 show an embodiment of stent graft according to the presentinvention. In this embodiment the tubular body 52 of this embodiment ofstent graft 50 comprises a proximal portion 54, an intermediate portion56 and a distal portion 58 as shown in FIG. 5.

Referring to FIG. 1 it can be seen that the proximal portion 54comprises a tubular body of a biocompatible graft material and issupported by self expanding zig zag stents 60 a and 60 b. The stent 60 ais internal to provide a smooth sealing surface to engage against thewall of the ascending aorta, and the stent 60 b is external. Theproximal portion may have a diameter from 35 to 50 mm.

The distal portion 58 is again formed from a tubular body of abiocompatible graft material and is supported by self expanding zig zagstents 82 and 84. The distal portion 58 can have a diameter in the rangeof from 30 to 40 mm.

The intermediate portion 56 is supported by self expanding zig zagstents 64 and 66 and is the region into which are placed the diamondshaped regions and the recess according to the present invention. Theintermediate portion has a diameter in the range from 20 to 30 mm andhad tapered portions at each end to connect with the proximal and distalportions respectively.

The stents 64, 66 and 68 comprise a plurality of struts and bends, thebends between the adjacent struts. In the embodiment shown, the strutsare substantially longer than the bends, the bends having a relativelysmall radius. The stents are made from shape memory wire in the form ofnitinol (metal alloy of nickel and titanium).

The intermediate portion 56 has a diameter at its proximal end 61 whichis substantially the same as the diameter of the proximal portion 54 anda diameter at its distal end which is substantially the same as thediameter of the distal portion 58. The intermediate portion 56 has most,if not all of its taper between the diameter of the proximal portion andthe diameter of the distal portion on the outside 72 of the curve of thestent graft.

As can be seen in FIG. 1 the intermediate portion 56 has two aperturesor fenestrations 74 and 75 which open into respective recesses 76 and 77within the step portion and graft tubes from the recesses extendsproximally towards the proximal portion 54. As shown in FIGS. 1 and 2,the recesses 76 and 77 are inclined relative to the longitudinal axis ofthe stent graft.

Adjacent stents 64 and 66 are positioned such that they define a diamondshape region 76 a. The diamond shape arises from having a pair of distalbends 64 b and 64 d of stent 64 aligned with a pair of proximal bends 66b and 66 d of stent 66 as is clearly shown in FIG. 1. A first pair ofadjacent struts 64 b′ and 64 c′ of stent 64 and a second pair ofadjacent struts 66 b′ and 66 c′ of the adjacent stent 66 together definea diamond shaped region 76 a.

A recess 76 lies within the diamond shape region 76 a. A fenestration 74into the tubular body leads from recess 76 into a graft tube 78. Thegraft tube 78 extends within the tubular body towards a proximal end ofthe stent graft as is most clearly shown in the cross-sectional view ofFIG. 5.

A third adjacent stent 68 has a pair of bends 68 a and 68 c adjacent tothe second stent 66 such that a third pair of adjacent stents 68 a′ and68 b′ define a second diamond shape region 77 a. The second diamondshape region 77 a shares a strut 66 b′ with the first diamond shaperegion 76 a.

In this particular embodiment stent 64 has fourteen bends (seven distalbends and seven proximal bends) and stent 66 has twelve bends (sixdistal bends and six proximal bends). As a result of the differingnumber of bends and the alignment described above, distal bends of stent64 are not aligned with proximal bends of stent 66 at the inside radiusof the stent graft, the side of the stent graft without the diamondshaped regions, when it is placed in the arch as illustrated in FIG. 6.This assists in providing flexibility so as to facilitate the stentgraft conforming to the anatomy of the thoracic arch as is shown in FIG.6. In other embodiments different numbers of struts and bends may beused. In general, however, it is preferable for adjacent stents to havedifferent numbers of struts and bends so that on the side of the stentgraft without the fenestrations and recesses the bends do not coincidethereby allowing better flexibility.

The diamond shape regions and recesses 76 a and 77 a facilitateinsertion of guide wires from the major branch arteries (such as thebrachiocephalic and the left carotid artery) into the internal tubes 78and 80 of the stent graft 50.

With the embodiment shown in FIGS. 1 to 6, the diamond shape regions 76a and 77 a are adjacent each other and are separated by a strut 66 b′ ofstent 66. With this arrangement, the corresponding fenestrations 74 and75 are offset from each other so that one is slightly more ventral thanthe other with respect to the thoracic arch.

The recess 76 within the intermediate portion 56 opens at its proximalend into a tube 78 and the recess 77 opens at its proximal end into atube 80. Each of the tubes may be of the same diameter or the uppermostof the tubes 78 may have a diameter which is greater than the diameterof the lower tube 80. The tubes 78 and 80 extend towards the proximalend 61 of the stent graft 50.

The proximal end of the tubes 78 and 80 are held open by reinforcingwires, or wire portions, 78 a and 80 a respectively, these wiresarranged to form circles as is shown in the cross-sectional view of FIG.5.

The tubes 78 and 80 also have reinforcing wires, or wire portions, 78 band 80 b arranged to hold the respective distal ends of the tubes openas is more clearly shown in FIG. 3.

Extending from reinforcing wire 78 a, past reinforcing wire 78 b and tobend 66 c is a longitudinal reinforcing wire, or wire portion 78 c as ismost clearly shown in FIG. 1. Similarly, extending from reinforcing wire78 a, past reinforcing wire 80 a and to bend 68 b is a longitudinalreinforcing wire, or wire portion 80 c.

Each of the smaller internal tubes 78 and 80 can be reinforced with ahelical shape memory wire reinforcement. Helical reinforcement for graftmaterial is shown in U.S. patent application Ser. No. 12/261,860entitled “Flexible Stent Graft” and the teachings therein areincorporated herein in their entirety.

FIG. 6 shows a schematic view of the placement of a stent graftaccording to one embodiment of the present invention into the thoracicarch of a patient.

The thoracic arch shown schematically comprises an ascending aorta 90extending to the thoracic arch 92 and a descending aorta 94 from thethoracic arch. Substantially at the top of the thoracic arch butslightly to the ventral side of the arch the major vessels branch offthe arch. The major vessels are the brachiocephalic artery 96, the leftcommon carotid artery 98 and the left subclavian 100. In a preparatoryoperation an anastomosis 102 is provided between the common carotidartery 98 and the left subclavian 100. The anastomosis provides accessbetween the common carotid artery 98 and the left subclavian artery 100which enables endovascular access to the stent graft via brachialarteries in the left arm rather than endovascular access via the leftcarotid artery which may be more complex.

The stent graft 50 is deployed into the thoracic arch such that theintermediate portion 56 is just proximal of the junction of the aortawith the brachiocephalic artery 96. This means that there is definedbetween the intermediate portion 56, the upper wall of the thoracic archand the distal portion 58 of the stent graft 50, an open region 111 sothat circulation can be preserved to the major vessels through theinternal tubes 78 and 80 and the recess 76 (see FIGS. 3 and 4) duringthe operation of deployment of the stent graft and subsequent placementof side branch grafts. The space also assists in enablingcatheterisation of the internal tubes. A catheter 110 can be inserted toenter the larger of the tubes 78 to enable placement of a side branchstent graft 114 for the brachiocephalic artery 96 and a catheter 112 canbe inserted to enter the smaller of the tubes 80 to enable placement ofa side branch stent graft 116 for the common carotid artery 98 and theleft subclavian artery 100. Subsequently a side branch stent graft canbe deployed from the respective branch artery into one of the smallertubes to provide blood flow into that branch artery.

Because the space 111 provides maintenance of circulation to the majorvessels there may be circumstances where an operation can be carried outin stages.

In a preferred embodiment the larger of the internal tubes 78 has adiameter of from 8 to 12 mm and the smaller of the tubes has a diameterof from 8 to 10 mm.

The graft tubes extending into the main lumen can have a reinforcementin the form of a space frame. The components of the space frame can bean assembly of two ring and strut components. Each ring and strutcomponent comprises a circular ring portion defining a plane of thecircular ring portion and a strut extending at right angles to the planeof the circular ring portion from a periphery of the circular ringportion. Each of the two ring and strut components are formed from asingle length of a rigid but resilient wire such as a nickel titaniumalloy wire. At each end of each piece of wire a loop is formed to ensurethat a sharp end which could puncture a vessel wall is not present. Oncethe components of the lightweight space frame are formed they havestitched to them portions of biocompatible graft material to formseparately the tubular portion 78, 80 and the enlarged funnel portion 76b, 77 b and then these are joined together by stitching or the like toform the internal tubes or branches 78, 80 and the recesses 76, 77.FIGS. 5 and 6 show the tubular portions 78, 80 and enlarged funnelportions 76 b, 77 b as they are attached to the graft to form therecesses and internal branches.

FIG. 7 shows an alternative embodiment. This embodiment is similar tothat shown in FIGS. 1 to 6 but it includes a third diamond shaped region47 a with its corresponding recess 47 and fenestration 45. In otherembodiments, not shown, there can be a single diamond shaped region,multiple diamond shaped regions aligned longitudinally or other layoutsof the regions. As further shown in FIGS. 1, 5, 6 and 7, the recesses47, 76 and 77 are oblong and have two sides tapering or convergingtoward the fenestrations of the internal branches and two sides taperingor converging toward the distal end of the recess. As shown, the firsttwo sides tapering or converging toward the fenestration are shorterthan the sides tapering or converging toward the distal ends of therecesses.

Many modifications and other embodiments of the invention will come tothe mind of one skilled in the art having the benefit of the teachingspresented in the foregoing descriptions and associated drawings.Therefore, it is understood that the invention is not to be limited tothe specific embodiments disclosed, and that modifications andembodiments are intended to be included within the scope of the appendedclaims.

1. A stent graft for placement in a vessel of a patient, the stent graftcomprising: a tubular body of graft material, the tubular body having aproximal inflow end, a distal outflow end, a main lumen therethrough, alongitudinal axis, a sidewall from the proximal inflow end to the distaloutflow end; a plurality of stents along the tubular body, including afirst stent, a second stent adjacent the first stent, and a third stentadjacent to the second stent, each of the first, second and third stentshaving first and second struts defining an apex, wherein the first andsecond struts and apex of the first stent and the first and secondstruts and apex of the second stent define a first diamond shaped regionof graft material and the first and second struts and apex of the secondstent and the first and second struts and apex of the third stent definea second diamond shaped region of graft material; a first recessedregion in the graft material in the first diamond shaped region, thefirst recessed region defined by a recessed portion of the graftmaterial of the tubular body that extends into the main lumen of thetubular body and a second recessed region in the second diamond shapedregion defined by a second recessed portion of the graft material of thetubular body that extends into the main lumen of the tubular body,wherein the first diamond shaped region and the second diamond shapedregion share a boundary; a first fenestration in the first recessedregion, a second fenestration in the second recessed region, each of thefirst and second fenestrations opening into the tubular body, whereinthe first and second fenestrations are both circumferentially andlongitudinally offset from each other.
 2. The stent graft of claim 1,wherein the first diamond shaped region and the second diamond shapedregion are at least partially longitudinally and circumferentiallyoffset from each other.
 3. The stent graft of claim 1, furthercomprising a third diamond shaped region longitudinally offset from thefirst and second diamond shape regions and circumferentially offset fromone of the first and second diamond shape regions, third diamond shapedregion having a third recessed region in the graft material in the thirddiamond shaped region, the third recessed region defined by a recessedportion of the graft material of the tubular body that extends into themain lumen of the tubular body.
 4. The stent graft of claim 3, furthercomprising a third fenestration in the third recessed region of thegraft material.
 5. The stent graft of claim 4, further comprising atubular graft extending from each of the first and second fenestrationsand into the main lumen of the tubular body.
 6. The stent graft of claim5, further comprising a tubular graft extending from the thirdfenestration and into the main lumen of the tubular body.
 7. The stentgraft of claim 5, wherein each tubular graft comprises a tubular portionand a funnel portion.
 8. The stent graft of claim 7, wherein the funnelportion of the tubular graft extending from the first fenestration formsthe first recessed region and the funnel portion of the tubular graftextending from the second fenestration forms the second recessed region.9. The stent graft of claim 6, wherein the tubular graft extending fromthe third fenestration comprises a tubular portion and a funnel portion,and wherein the funnel portion of the tubular graft extending from thethird fenestrations forms the third recessed region.
 10. The stent graftof claim 8, wherein each of the funnel portions is inclined relative tothe longitudinal axis of the stent graft.
 11. A stent graft forplacement in vessel of a patient, the stent graft comprising; a tubularbody of graft material, the tubular body defining a main lumentherethrough, a longitudinal axis, the graft material defining a sidewall, a plurality of stents along the tubular body, each of the stentscomprising a plurality of struts and apices, each of the apices disposedbetween a pair of adjacent struts; a first shaped region in the sidewall of the graft material of the tubular body having a perimeter, theperimeter being formed at least in part by two adjacent struts and aapex of a first stent of the plurality of stents and two adjacent strutsand an apex of a second adjacent stent of the plurality of stents; asecond shaped region in the side wall of the graft material of thetubular body longitudinally and circumferentially offset from the firstshaped region and having a perimeter, the perimeter being formed atleast in part by two adjacent struts of the second stent of theplurality of stents and two adjacent struts of a third adjacent stent ofthe plurality of stents, wherein the first shaped region and the secondshaped region share a boundary at one of the two adjacent struts of thesecond stent; a first recess in the first shaped region, the firstrecess defined by a recessed portion of the graft material that extendsinto the main lumen of the tubular body; a second recess in the secondshaped region, the second recess defined by a recessed portion of thegraft material that extends into the main lumen of the tubular body; afirst fenestration in the first recessed portion of graft material, thefirst fenestration opening into the tubular body from the first shapedrecess; a second fenestration in the second recessed portion of graftmaterial, the second fenestration opening into the tubular body from thesecond shaped recess; a first graft tube leading from the firstfenestration into the main lumen toward an end of the stent graft; and asecond graft tube leading from the second fenestration into the mainlumen toward an end of the stent graft.
 12. The stent graft of claim 11,wherein the first fenestration and the second fenestration are bothlongitudinally and circumferentially offset from each other.
 13. Thestent graft of claim 11, wherein the end of the stent graft is aproximal inflow end and at least one of the first and second tubesextends toward the proximal inflow end.
 14. The stent graft of claim 11,wherein each of the first and second tubes has a proximal end and theproximal ends of the first and second tubes are both longitudinally andcircumferentially offset from each other.
 15. The stent graft of claim11, wherein each of the first and second tubes comprises a tubularportion and a funnel portion attached to a distal end of the tubularportion.
 16. The stent graft of claim 15, wherein the funnel portion ofthe first tube forms the first recess and the funnel portion of thesecond tube forms the second recess.
 17. The stent graft of claim 16,wherein each of the funnel portions is inclined relative to thelongitudinal axis.
 18. A stent graft for placement in vessel of apatient, the stent graft comprising; a tubular body of graft material,the tubular body defining a main lumen therethrough, a longitudinalaxis, the graft material defining a side wall, a proximal inflow end, adistal outflow end, and a plurality of stents along the tubular body,each of the stents comprising a plurality of struts and apices, each ofthe apices disposed between a pair of adjacent struts; at least oneshaped region in the side wall of the graft material of the tubular bodyhaving a perimeter, the perimeter being formed at least in part by twoadjacent struts and a apex of a first stent of the plurality of stentsand two adjacent struts and an apex of a second adjacent stent of theplurality of stents; a recess in the at least one shaped region, therecess defined by a recessed portion of the graft material that extendsinto the main lumen of the tubular body; a first fenestration in the atleast one recessed portion of graft material, the first fenestrationopening into the main lumen; a single graft tube leading from thefenestration into the main lumen toward the proximal inflow end; asecond fenestration in the graft material of the sidewall, the secondfenestration longitudinally and circumferentially offset from the firstfenestration; wherein the single graft tube comprises a tubular portionand a funnel portion at a distal end of the single graft tube and havinga width greater than the diameter of the tubular portion, the funnelportion forming the recess and providing a smooth uninterrupted pathinto the tubular portion.
 19. The stent graft of claim 18, wherein thefunnel portion is inclined relative to the longitudinal axis of thetubular body.
 20. The stent graft of claim 18, wherein the at least oneshaped region is a diamond shaped region.